Perelman School of Medicine at the University of Pennsylvania
Pioneer in the development of gene transfer therapies
Carl H. June, MD, is the Richard W. Vague Professor in Immunotherapy
in the Department of Pathology and Laboratory Medicine in the Perelman
School of Medicine at the University of Pennsylvania, and director
of Translational Research in the Abramson Cancer Center. His work and
accomplishments include:
Published the first round of groundbreaking results that detailed the
world’s first successful and sustained demonstration of the use of chimeric
antigen receptor (CAR) gene transfer therapy to create designer
T cells aimed at battling cancerous tumors. The treatment has since
been used with promising results to treat both children and adults with
refractory acute lymphoblastic leukemia.
Founded the Immune Cell Biology Program and was head of the
Department of Immunology at the Naval Medical Research Institute
from 1990 to 1995 before joining the faculty of the Perelman School
of Medicine in 1999
Investigating various mechanisms of lymphocyte activation that
relate to immune tolerance and adoptive immunotherapy for cancer
and chronic infection
Recognized with numerous awards, including the 2002 Lifetime
Achievement Award from the Leukemia and Lymphoma Society of
America and the Joan Miller and Linda Bernstein Gene Therapy Ovarian
Cancer Award from the Alliance for Cancer Gene Therapy