IMMUNO-ONCOLOGY
Carl H. June, MD
Perelman School of Medicine at the University of Pennsylvania
Pioneer in the development of gene transfer therapies
- Carl H. June, MD, is the Richard W. Vague Professor in Immunotherapy
in the Department of Pathology and Laboratory Medicine in the Perelman
School of Medicine at the University of Pennsylvania, and director
of Translational Research in the Abramson Cancer Center. His work and
accomplishments include:
- Published the first round of groundbreaking results that detailed the world’s first successful and sustained demonstration of the use of chimeric antigen receptor (CAR) gene transfer therapy to create designer T cells aimed at battling cancerous tumors. The treatment has since been used with promising results to treat both children and adults with refractory acute lymphoblastic leukemia.
- Founded the Immune Cell Biology Program and was head of the Department of Immunology at the Naval Medical Research Institute from 1990 to 1995 before joining the faculty of the Perelman School of Medicine in 1999
- Investigating various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection
- Recognized with numerous awards, including the 2002 Lifetime Achievement Award from the Leukemia and Lymphoma Society of America and the Joan Miller and Linda Bernstein Gene Therapy Ovarian Cancer Award from the Alliance for Cancer Gene Therapy
