Giants of Cancer CareĀ® Program Inductees


James F. Holland, MD

Icahn School of Medicine at Mount Sinai

  • James F. Holland, MD, is the Distinguished Professor of Neoplastic Diseases at the Icahn School of Medicine at Mount Sinai in New York and practices in hematology-oncology at The Mount Sinai Hospital.
  • Created the first combination chemotherapy program in acute leukemia at the NCI in 1953, resulting in the formation of Acute Leukemia Group B, a research collaboration that later became known as the Cancer and Leukemia Group B.
  • Worked with Emil J. Freireich, MD, to develop the POMP chemotherapy combination of methotrexate, mercaptopurine, vincristine, and prednisone for children with acute lymphoblastic leukemia.
  • Constructed the 7 + 3 regimen for administering cytarabine and daunorubicin to adults with acute myeloid leukemia.
  • First identified cisplatin for the treatment of patients with testicular cancer and doxorubicin for individuals with osteosarcoma.
  • Co-authored the Cancer Medicine textbook with Freireich and Emil Frei III, MD, which has become an influential oncology reference book now in its eighth edition.
  • Served as special consultant for a cancer research initiative in the former USSR in 1972-1973.
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