Giants of Cancer Care® Program Inductees
Lymphoma
Steven T. Rosen, MD
City of Hope Comprehensive Cancer Center
- Rosen is provost and chief science officer, director of the Comprehensive Cancer Center, the Irell & Manella Cancer Center Director’s Distinguished Chair, the Morgan & Helen Chu Director’s Chair and director of the Beckman Research Institute, and director of the Irell & Manella Graduate School of Biological Sciences at City of Hope.
- Rosen was previously director of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University for 24 years. The National Cancer Institute (NCI) named Lurie an NCI-designated comprehensive cancer center under Rosen’s leadership.
- Rosen is a pioneer in the development monoclonal antibodies and recombinant toxins that can specifically target cancer cells.
- He led pivotal research into apoptosis inducers, proteasome inhibitors, and metabolism inhibitors to promote cancer cell death. His research also led to the discovery that RNA-based analogs and cell signaling regulators that can interfere with cancer growth processes.
- Rosen has been a leader in the discovery of how interferons and cytokines that can trigger an immune response against cancer cells and how angiogenesis inhibitors to prevent cancer from growing new blood vessels.
- He has been at the forefront of research into hormone therapies and transcriptional regulators and antisense compounds to activate or silence certain genes in cancer and normal cells.
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