Giants of Cancer Care® Program Inductees

Prevention/Genetics

Deborah Schrag, MD, MPH

Memorial Sloan Kettering Cancer Center

Schrag is chair of the Department of Medicine and the George J. Bosl Chair at Memorial Sloan Kettering Cancer Center.
Her research efforts focus on care delivery innovation, which includes health system–level interventions and practical clinical trials. Previously, she established and led the Clinical Effectiveness Program at the Harvard T.H. Chan School of Public Health.
Schrag is leading the ongoing prospective interventional multicenter PATHFINDER study (NCT04241796), which is evaluating the application of an earlier version of the Galleri test in clinical practice. Galleri uses a single blood draw to detect multiple cancer types.
Findings from PATHFINDER, which enrolled 6600 patients, presented at the European Society for Medical Oncology Congress 2022 showed the feasibility of Galleri as a potential screening method that complements existing modalities.
Schrag is the principal investigator for the ongoing multicenter National Cancer Institute–run phase 2/3 PROSPECT trial (NCT01515787), which is evaluating FOLFOX (folinic acid, fluorouracil, and oxaliplatin) vs 5-fluorouracil/capecitabine and radiation therapy prior to surgery in patients with locally advanced rectal cancer.

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